Detective Jane Rizzoli and medical examiner Maura Isles investigate the grisly murder of a wealthy couple. The M.O. matches the work of a serial killer known as the Surgeon, who once nearly murdered Jane. Now that the Surgeon is behind bars, it seems one of his protégés is picking up where he left off.
Jane and Maura investigate the mysterious death of a young boy that may point to an attempted exorcism, leading Rizzoli to suspect his pastor. Meanwhile, Jane's mother sets her up on a surprise date.
A member of a Boston "Brahmin" family is the victim of an apparent sailing accident. Maura's close family connection and Jane's resentment over the family's display of wealth causes friction between the two which affects the investigation. Angela tries selling a health drink.
Jane goes undercover to solve the case of a woman who was murdered after leaving a lesbian bar. Maura drags Jane to yoga class and hooks her up with a fellow yogi.
A shooter targets runners at The Boston Marathon. Jane and Maura must conduct their investigation in secret to avoid a panic and catch the killer before another shooting.
Killers of an undercover narcotics cop target Boston homicide headquarters putting Jane, Maura and Frankie Jr. in a fight for their lives. Meanwhile, Angela and Frank eagerly await the return of their son, Tommy, who's being released from prison.